Systematic Exploration of Indolizine-Based Small Fluorescent Molecules Synthesis, Analysis and Application /

This thesis describes an in-depth study of an indolizine-based fluorophore, from understanding of its structure-photophysical property relationship to its application as a useful biological reporter. Organic fluorophores have been extensively used in the field of molecular biology owing to their exc...

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Bibliographic Details
Main Author: Lee, Youngjun (Author)
Corporate Author: SpringerLink (Online service)
Format: e-Book
Language:English
Published: Singapore : Springer Nature Singapore : 2018.
Imprint: Springer,
Edition:1st ed. 2018.
Series:Springer Theses, Recognizing Outstanding Ph.D. Research,
Subjects:
Biotechnology.
Bioorganic chemistry.
Biophysics.
Biomedical engineering.
Industrial microbiology.
Chemical Bioengineering.
Bioorganic Chemistry.
Biomedical Engineering and Bioengineering.
Industrial Microbiology.
Online Access:Full-text access
Description
Summary:This thesis describes an in-depth study of an indolizine-based fluorophore, from understanding of its structure-photophysical property relationship to its application as a useful biological reporter. Organic fluorophores have been extensively used in the field of molecular biology owing to their excellent photophysical property, suitable cell permeability, and synthetic flexibility. Understanding of the structure-photophysical property relationship of a given fluorophore often paves the road to the development of valuable molecular probes to visualize and transcribe biological networks. In this thesis, respective chapters deal with molecular design, organic synthesis, structure-property analysis, and quantum-mechanical interpretation of unexplored family of indolizine-based molecules. This systematic exploration has led to rational development of a new microalgae lipid droplet probe, colorful bioorthogonal fluorogenic probes, and a bright mitochondrial probe, working under livecell conditions. Harnessing the optical properties of a given fluorophore has been an important topic for a couple of decades, both in industry and in academia. This thesis provides useful insights for the improvement and development of unique small fluorescent materials, or optical materials.
Physical Description:XXV, 187 p. 197 illus., 90 illus. in color. online resource.
ISBN:9789811316456
ISSN:2190-5061
DOI:10.1007/978-981-13-1645-6

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