HCV: The Journey from Discovery to a Cure Volume I /

Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) and infects approximately 75 million individuals worldwide. It is also one of the major causes of liver cancer and liver transplants. The elucidation of the HCV genome, and the development of a whole cell system to study the virus...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Sofia, Michael J. (Editor)
Format: e-Book
Language:English
Published: Cham : Springer International Publishing : 2019.
Imprint: Springer,
Edition:1st ed. 2019.
Series:Topics in Medicinal Chemistry, 31
Subjects:
Medicinal chemistry.
Virology.
Clinical biochemistry.
Bioorganic chemistry.
Pharmaceutical chemistry.
Medicinal Chemistry.
Medical Biochemistry.
Bioorganic Chemistry.
Pharmaceutics.
Online Access:Full-text access
Table of Contents:
  • Identification of the virus, the medical need and clearing the blood supply
  • Mapping the HCV genome
  • The molecular virology of HCV
  • The development of the HCV replicon system
  • The Evolution of IFN therapy for HCV
  • Evolution of HCV NS5B Non-Nucleoside Inhibitors
  • Evolution of HCV NS5B Nucleoside & Nucleotide Inhibitors
  • Discovery and Development of Sofosbuvir
  • Discovery of Beclabuvir
  • Discovery of Dasabuvir
  • Evolution of HCV NS3/4 protease inhibitors
  • Discovery and Development of Telaprevir
  • Discovery and Development of Boceprevir
  • Discovery and Development of Asunaprevir.-Discovery and Development of Grazoprevir
  • Discovery and Development of Simeprevir
  • Discovery and Development of Paritaprevir & Glecaprevir.

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