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Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds
This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. The material outlined in...
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| Müşterek Yazar: | |
| Materyal Türü: | e-Kitap |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
Cham :
Springer International Publishing :
2016.
Imprint: Springer, |
| Edisyon: | 1st ed. 2016. |
| Seri Bilgileri: | Springer Theses, Recognizing Outstanding Ph.D. Research,
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| Konular: | |
| Online Erişim: | Full-text access |
| Özet: | This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source. McDonald's findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. . |
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| Fiziksel Özellikler: | XXIII, 144 p. 8 illus. online resource. |
| ISBN: | 9783319388786 |
| ISSN: | 2190-5061 |
| DOI: | 10.1007/978-3-319-38878-6 |