Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches

This thesis describes the authors' pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a ric...

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Bibliographic Details
Main Author: Wong, Daniel Yuan Qiang (Author)
Corporate Author: SpringerLink (Online service)
Format: e-Book
Language:English
Published: Singapore : Springer Nature Singapore : 2018.
Imprint: Springer,
Edition:1st ed. 2018.
Series:Springer Theses, Recognizing Outstanding Ph.D. Research,
Subjects:
Medicinal chemistry.
Clinical biochemistry.
Cancer.
Medicinal Chemistry.
Medical Biochemistry.
Cancer Biology.
Online Access:Full-text access
Table of Contents:
  • Introduction- Cisplatin- Now and Future
  • Harnessing Chemoselective Imine Ligation for Tethering Bioactive Molecules to Platinum (IV) Prodrugs
  • Probing the Platinum(IV) Prodrug Hypothesis - Are Platinum(IV) Complexes Really Prodrugs of Cisplatin?
  • Induction of Targeted Necrosis with HER2-Targeted Platinum(IV) Anticancer Prodrugs
  • Immuno-Chemotherapeutic Platinum(IV) Prodrugs of Cisplatin as Multimodal Anticancer Agents
  • Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes
  • Concluding Remarks.

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