Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches

This thesis describes the authors' pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a ric...

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Detaylı Bibliyografya
Yazar: Wong, Daniel Yuan Qiang (Yazar)
Müşterek Yazar: SpringerLink (Online service)
Materyal Türü: e-Kitap
Dil:İngilizce
Baskı/Yayın Bilgisi: Singapore : Springer Nature Singapore : 2018.
Imprint: Springer,
Edisyon:1st ed. 2018.
Seri Bilgileri:Springer Theses, Recognizing Outstanding Ph.D. Research,
Konular:
Medicinal chemistry.
Clinical biochemistry.
Cancer.
Medicinal Chemistry.
Medical Biochemistry.
Cancer Biology.
Online Erişim:Full-text access
İçindekiler:
  • Introduction- Cisplatin- Now and Future
  • Harnessing Chemoselective Imine Ligation for Tethering Bioactive Molecules to Platinum (IV) Prodrugs
  • Probing the Platinum(IV) Prodrug Hypothesis - Are Platinum(IV) Complexes Really Prodrugs of Cisplatin?
  • Induction of Targeted Necrosis with HER2-Targeted Platinum(IV) Anticancer Prodrugs
  • Immuno-Chemotherapeutic Platinum(IV) Prodrugs of Cisplatin as Multimodal Anticancer Agents
  • Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes
  • Concluding Remarks.

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