Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies

This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway...

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Detaylı Bibliyografya
Yazar: Bi, Yunchen (Yazar)
Müşterek Yazar: SpringerLink (Online service)
Materyal Türü: e-Kitap
Dil:İngilizce
Baskı/Yayın Bilgisi: Berlin, Heidelberg : Springer Berlin Heidelberg : 2018.
Imprint: Springer,
Edisyon:1st ed. 2018.
Seri Bilgileri:Springer Theses, Recognizing Outstanding Ph.D. Research,
Konular:
Biomedical engineering.
Biophysics.
Biological transport.
Cell membranes.
Immunology.
Atomic structure  .
Molecular structure .
Biomedical Engineering and Bioengineering.
Membrane Trafficking.
Atomic and Molecular Structure and Properties.
Online Erişim:Full-text access
İçindekiler:
  • Introduction
  • Review
  • Nanodisc assembly and the study on the interaction between the lipid and ion
  • Calcium regulates T cell receptor activation through phospholipid electrostatic manipulation
  • The preliminary study on the structure of Dengue Virus NS2B-NS3p in complex with aprotinin
  • Summary and prospect of this dissertation.

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