Synthesis and Biological Evaluation of Pyrrole-Imidazole Polyamide Probes for Visualization of Telomeres

This book presents a novel method of synthesizing sequence-specific DNA binding pyrrole-imidazole (Py-Im) polyamides and demonstrates polyamides targeting longer base pairs than those previously reported and their cellular application. It discusses the development of the facile synthetic method of t...

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Bibliographic Details
Main Author: Kawamoto, Yusuke (Author)
Corporate Author: SpringerLink (Online service)
Format: e-Book
Language:English
Published: Singapore : Springer Nature Singapore : Imprint: Springer, 2019.
Edition:1st ed. 2019.
Series:Springer Theses, Recognizing Outstanding Ph.D. Research,
Subjects:
Bioorganic chemistry.
Biomaterials.
Nucleic acids.
Bioorganic Chemistry.
Nucleic Acid.
Online Access:Full-text access
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Table of Contents:
  • 1. General Introduction Sequence-specific DNA Binding Pyrrole-Imidazole Polyamides and Their Applications
  • 2. Development of a New Method for Synthesis of Tandem Hairpin Pyrrole-Imidazole Polyamide Probes Targeting Human Telomeres
  • 3. Tandem Trimer Pyrrole-Imidazole Polyamide Probes Targeting 18 Base Pairs in Human Telomere Sequences
  • 4. Targeting 24 bp within Telomere Repeat Sequences with Tandem Tetramer Pyrrole−Imidazole Polyamide Probes. .

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