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New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations
This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and α,β-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of β-substituted nitroalkenes. The scope of Rauhut-Currier reaction was successfully extended to the most challenging β-...
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| Müşterek Yazar: | |
| Materyal Türü: | e-Kitap |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
Singapore :
Springer Nature Singapore :
2017.
Imprint: Springer, |
| Edisyon: | 1st ed. 2017. |
| Seri Bilgileri: | Springer Theses, Recognizing Outstanding Ph.D. Research,
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| Konular: | |
| Online Erişim: | Full-text access |
| Özet: | This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and α,β-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of β-substituted nitroalkenes. The scope of Rauhut-Currier reaction was successfully extended to the most challenging β-substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via γ-addition. Highly enantiopure tetrahydropyridazinones and γ-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available α,β-unsaturated carboxylic acids were first successfully employed to generate the α,β-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations. |
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| Fiziksel Özellikler: | XIV, 123 p. 66 illus., 13 illus. in color. online resource. |
| ISBN: | 9789811028991 |
| ISSN: | 2190-5061 |
| DOI: | 10.1007/978-981-10-2899-1 |